Topol highlights findings that semaglutide cut proteomic organ age by 2 to 4 years on heart, artery and kidney clocks.
Recap by typeshit. Post by Eric Topol on X.
An explainer on how GLP-1 drugs act on reward and craving in the brain, and the research testing them against alcohol, nicotine and other substance use.
Dr Alo, a cardiologist, says he is following the cardiovascular data on these drugs closely and that it is shifting how heart disease is treated.
Robert Lufkin MD shares the observational data: an average 16.1 kg lost at six months among 7,297 women, with 62.7% reporting side effects.
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DOWNSIZED looks at why appetite and food noise can creep back late in the weekly cycle, and what that may say about whether a GLP-1 is still working.
The investor piece cites retatrutide's 28.3% mean weight loss in an 80-week Phase 3 study and Lilly's push into combo and maintenance dosing.
His timeline lists each drug with average weight loss, from about 3 to 5% on Orlistat to around 9 to 10% on Qsymia, showing how far the field has moved.
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