Three posters at ObesityWeek, Nov. 14 to 17, compare it to orforglipron in mice and primates. The company plans to file for human trials in early 2027.
Recap by typeshit. Full story at Longevity.Technology.
A Facebook share says Danish teams found certain bacterial strains may change how the gut tells the brain it is full. The work so far is in animal models only.
Bikman calls the results remarkable, but he argues that bigger drops make it more important to know how much of the lost weight is fat and how much is muscle.
Bikman points out that weight usually returns once the drug is stopped, which makes the question of lifelong use a real one.
Avi Roy flags a preprint that pooled 10,052 people from five semaglutide trials and used a blood test to estimate heart age. It has not yet been peer reviewed.
The This Is Us actress says the drug eased her inflammation and quieted food noise, after losing 100 pounds last year.
Johns Hopkins doctor Yuval Pinto points to undereating, dehydration and low nutrients. Trial data put Wegovy fatigue at about 11% versus 5% on placebo.
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