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Published in NEJM, the 80-week trial of 2,339 adults with obesity saw weight drop up to 25% on the 12 mg dose, with researchers reporting pain cut by as much as 61.6%.
Recap by typeshit. Full story at Healio.
The candidate blocks a signal behind appetite loss and high energy burn in cancer cachexia, where patients waste away even while eating.
The new preprint looks at whether symptom relief people report on GLP-1 medications comes from weight loss alone or something else.
Lilly says participants lost 44 to 47 pounds versus about 21 on Ozempic, with bigger A1C drops. It plans to file for approval in 2027.
Lilly reports people on retatrutide lost 44 to 47 pounds over 80 weeks versus about 21 on Ozempic. It plans to file for approval in 2027.
Hims & Hers and a peptide academy met White House reviewers before release, and the Partnership for Safe Medicines has petitioned the FDA to block it.
On his podcast, Khan cites studies suggesting hunger hormones rebound within four weeks and about 60% of lost weight comes back within a year.
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