Marchione makes the case for pairing GLP-1s with drugs that target amylin, the hormone released after meals that signals fullness to the brain.
Recap by typeshit. Post by Max Marchione on X.
The once-daily pill blocks the IL-23 receptor and helped people with moderate to severe ulcerative colitis respond more often than placebo, a new study reports.
Bikman welcomes a new result but argues the likely cause is tirzepatide bringing insulin down rather than the drug slowing aging itself. His view, not a study claim.
Regen says the placebo group saw a 9% drop, while people on retatrutide also lost 31 lb on average and saw systolic blood pressure fall 14 points.
He points to a November 2026 study he says suggests semaglutide and other GLP-1 drugs may help beyond diabetes and obesity in people with schizophrenia.
Dr. Nadolsky responds to a clip from comedian @stavvybaby2 about GLP-1s, adding a doctor's view to the joke.
He calls GLP-1 drugs useful before surgery or after regain, but says surgery stays the main option for people who need large, lasting weight loss.
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