Mgoes highlights the figures, including up to 30% at two years in the extension. The drug is still in phase 3 and not approved.
Recap by typeshit. Post by Mgoes (bio/acc 🤖💉) on X.
A Facebook share says Danish teams found certain bacterial strains may change how the gut tells the brain it is full. The work so far is in animal models only.
Bikman calls the results remarkable, but he argues that bigger drops make it more important to know how much of the lost weight is fat and how much is muscle.
Bikman points out that weight usually returns once the drug is stopped, which makes the question of lifelong use a real one.
Avi Roy flags a preprint that pooled 10,052 people from five semaglutide trials and used a blood test to estimate heart age. It has not yet been peer reviewed.
A rundown of two Phase III head-to-head trials comparing Novo's CagriSema with tirzepatide in adults with type 2 diabetes.
The endocrinologist cautions that an interesting effect seen in animals does not mean a compound is suitable for human use.
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